Efficacy of combined modality therapy for intractable difficult-to-treat rhinosinusitis / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To investigate the clinical effects of the combined modality therapy for the patients with difficult-to-treat rhinosinusitis (DTRS).@*METHOD@#The clinical data involving 42 patients with DTRS were analyzed retrospectively. All patients received revision endoscopic sinus surgery (ESS) and combined modality therapy systematically and individually. The clinical effects of all patients were observed 6- and 12-month following revision ESS.@*RESULT@#Forty-two patients were followed up for 6 months, whereas 35 patients were followed for 12 months post operation. VAS scores of the patients significantly improved (P 0.05) between 6- and 12-month post operation. Moreover, Lund-Kennedy scores by endoscopy significantly improved (P 0.05) between 6- and 12-month postoperatively. Additionally, within 6 months follow-up, 16 of 42 patients (38.1%) were cured, 19 of 42 patients (45.2%) were improved, and 7 of 42 patients (16.7%) were ineffective. The total effective rate in all patients was 83.3% 6 months postoperatively. While within 12 months follow-up, 11 of 35 patients (31.4%) were cured, 15 of 35 patients (42.9%) were improved, and 9 of 35 patients (25.7%) were ineffective. Hence, the total effective rate in 35 patients was 74.3% after 12-month follow-up. There was no statistic difference (χ² = 1.019, P > 0.05) between 6- and 12-month postoperatively.@*CONCLUSION@#Appropriate revision ESS plus the combined modality therapy has been proven to be an effective method for the treatment of DTRS. The clinical effects in this study are significant and stable, and thus it is worthy of further clinical applications.

Design, synthesis and evaluation of novel hydroxyethylamine derivatives with nitrogen heterocyclic moiety at N-terminal as BACE1 inhibitors / 国际药学研究杂志

Objective: To develop a new series of hydroxy ethylamine (HEA) BACE1 inhibitors with nitrogen heterocyclic moiety at N-terminal and find new N-terminal moiety for enhancing BACE1 inhibition activity. Methods: New HEA compounds with nitrogen heterocyclic moiety at N-terminal were synthesized and evaluated as BACE1 inhibitors,with (-)-epigallocatechin-3-gallate EGCG as a positive control. Results: All new compounds were characterized by 1H NMR and ESI-MS. Evaluation of BACE1 inhibition activity showed that the compound I6 with indole moiety at N-terminal had BACE1 inhibition activity. Conclusion: The results suggested that the indole moiety at N-terminal interact with S2 pocket of BACE1 and be favorable for enhancing BACE1 inhibition activity, Thus, the indole moiety at N-terminal can be used as lead structure for further finding more effient BACE1 inhibitors.

Peripheral facial paralysis in temporal bone trauma and cholesteatoma otitis media / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To investigate into the surgical approaches and clinical curative effect of peripheral facial nerve paralysis in different causes and injury location.@*METHOD@#Thirty-two cases of peripheral facial paralysis were treated with selective facial nerve decompression via different surgical approaches. After 0.5 year to 2 years follow up, the recovered functions of facial nerve were judged by House and Brackmann grading system.@*RESULT@#In all patients, 17 cases of peripheral facial paralysis caused by trauma were underwent facial nerve decompression in two weeks, 11 cases reached degree I (84.6%) according to House-Brackmann (H-B) facial nerve function scores, 3 cases were treated in the third week, 2 cases reached degree II and other 1 cases reached degree III. One patient was treated after 8 weeks and facial nerve function scores only reached degree VI. Thirteen cases of otomastoiditis in middle ear were underwent facial nerve decompression in one week, postoperative House-Brackmann grade was I in 8 cases, II in 2, and III in 4.@*CONCLUSION@#Majority of patients with peripheral facial paralysis were treated with facial nerve decompression have better clinical curative effect by suitable operation and juncture due to trauma or cholesteatoma otitis media, but operation for traumatic peripheral facial paralysis should be undertaken in two weeks.